| Oct. 8 | @ |  | Ottawa | W 2-1 |
| Oct. 9 | vs. |  | Rangers | L 6-3 |
| Oct. 11 | vs. |  | Chicago | L 4-3 |
| Oct. 13 | vs. |  | New Jersey | L 1-0 (OT) |
| Oct. 15 | vs. |  | Montreal | L 2-1 |
| Oct. 16 | @ | | Chicago | L 4-3 |
| Oct. 20 | @ |  | Atlanta | W 4-1 |
| Oct. 22 | vs. | | Ottawa | L 4-2 |
| Oct. 23 | @ | | New Jersey | W 6-1 |
| Oct. 26 | @ |  | Philadelphia | L 6-3 |
| Oct. 29 | @ | | Atlanta | L 4-3 (OT) |
| Oct. 30 | @ |  | Dallas | L 4-0 |
| Nov. 3 | vs. |  | Boston | L 5-2 |
| Nov. 5 | vs. | | Montreal | L 3-2 |
| Nov. 6 | @ |  | Toronto | W 3-2 (SO) |
| Nov. 10 | @ | | New Jersey | W 5-4 (SO) |
| Nov. 11 | @ | | Rangers | L 3-2 (OT) |
| Nov. 13 | vs. |  | Washington | W 3-2 (OT) |
| Nov. 15 | vs. |  | Vancouver | W 4-3 (OT) |
| Nov. 17 | @ | | Washington | L 4-2 |
| Nov. 19 | vs. |  | Los Angeles | W 4-2 |
| Nov. 20 | vs. |  | Tampa Bay | L 2-1 |
| Nov. 24 | vs. |  | Pittsburgh | L 1-0 |
| Nov. 26 | vs. | | Toronto | W 3-1 |
| Nov. 27 | @ | | Montreal | L 3-1 |
| Dec. 3 | vs. |  | Columbus | W 5-0 |
| Dec. 4 | @ | | Ottawa | W 1-0 (SO) |
| Dec. 7 | @ | | Boston | L 3-2 (OT) |
| Dec. 9 | vs. |  | San Jose | W 6-3 |
| Dec. 11 | vs. | | Pittsburgh | L 5-2 |
| Dec. 15 | vs. | | Boston | W 3-2 |
| Dec. 17 | @ |  | Florida | L 6-2 |
| Dec. 18 | @ | | Tampa Bay | L 3-1 |
| Dec. 21 | vs. |  | Anaheim | W 5-2 |
| Dec. 23 | vs. | | Florida | L 4-3 |
| Dec. 27 | @ |  | Calgary | L 5-2 |
| Dec. 28 | @ |  | Edmonton | W 4-2 |
| Jan. 1 | vs. | | Boston | W 7-6 (SO) |
| Jan. 4 | @ |  | Colorado | L 4-3 (OT) |
| Jan. 6 | @ | | San Jose | W 3-0 |
| Jan. 8 | @ |  | Phoenix | W 2-1 (OT) |
| Jan. 11 | vs. | | Philadelphia | L 5-2 |
| Jan. 13 | vs. |  | Carolina | W 3-2 |
| Jan. 15 | @ |  | Islanders | L 5-3 |
| Jan. 18 | vs. | | Montreal | W 2-1 (OT) |
| Jan. 20 | @ | | Boston | W 4-2 |
| Jan. 21 | vs. | | Islanders | L 5-2 |
| Jan. 23 | @ | | Islanders | W 5-3 |
| Jan. 25 | @ | | Ottawa | W 3-2 (SO) |
| Feb. 4 | @ | | Pittsburgh | L 3-2 |
| Feb. 5 | vs. | | Toronto | W 6-2 |
| Feb. 8 | @ | | Tampa Bay | W 7-4 |
| Feb. 10 | @ | | Florida | W 3-2 (OT) |
| Feb. 13 | vs. | | Islanders | L 7-6 (OT) |
| Feb. 15 | @ | | Montreal | W 3-2 (SO) |
| Feb. 16 | vs. | | Toronto | L 2-1 |
| Feb. 18 | vs. |  | St. Louis | L 3-0 |
| Feb. 20 | vs. | | Washington | L 2-1 |
| Feb. 23 | vs. | | Atlanta | W 4-1 |
| Feb. 25 | vs. | | Ottawa | W 4-2 |
| Feb. 26 | vs. |  | Detroit | L 3-2 (SO) |
| Mar. 1 | @ | | Rangers | W 3-2 |
| Mar. 3 | @ | | Carolina | L 3-2 (OT) |
| Mar. 5 | @ | | Philadelphia | W 5-3 |
| Mar. 6 | @ |  | Minnesota | W 3-2 (OT) |
| Mar. 8 | @ | | Pittsburgh | L 3-1 |
| Mar. 10 | @ | | Boston | W 4-3 (OT) |
| Mar. 12 | @ | | Toronto | L 4-3 |
| Mar. 13 | vs. | | Ottawa | W 6-4 |
| Mar. 15 | vs. | | Carolina | L 1-0 |
| Mar. 19 | vs. | | Atlanta | W 8-2 |
| Mar. 20 | vs. |  | Nashville | L 4-3 (OT) |
| Mar. 22 | @ | | Montreal | W 2-0 |
| Mar. 25 | vs. | | Florida | W 4-2 |
| Mar. 26 | vs. | | New Jersey | W 2-0 |
| Mar. 29 | @ | | Toronto | L 4-3 |
| Mar. 30 | vs. | | Rangers | W 1-0 |
| Apr. 2 | @ | | Washington | L 5-4 (OT) |
| Apr. 3 | @ | | Carolina | W 2-1 (OT) |
| Apr. 5 | vs. | | Tampa Bay | W 4-2 |
| Apr. 8 | vs. | | Philadelphia | W 4-3 (OT) |
| Apr. 9 | @ | | Columbus | W 5-4 |
Home 2010-2011 Schedule