- Regular Season
- Preseason
Regular Season
| # | Day | Date | H/A | Opponent | Time | Network |
|---|---|---|---|---|---|---|
| 1 | Thursday | 10/3 | Away |  Penguins | W 3-1 | |
| 2 | Saturday | 10/5 |  Home |  Devils | W 7-2 | |
| 3 | Monday | 10/7 | Away |  Blue Jackets | L 4-3 (OT) | |
| 4 | Wednesday | 10/9 | Home |  Canadiens | W 5-4 (OT) | |
| 5 | Friday | 10/11 | Home |  Panthers | W 3-2 (SO) | |
| 6 | Monday | 10/14 | Home |  Stars | W 4-0 | |
| 7 | Wednesday | 10/16 | Away |  Ducks | L 5-2 | |
| 8 | Thursday | 10/17 | Away |  Kings | W 3-0 | |
| 9 | Saturday | 10/19 | Away |  Sharks | W 4-3 | |
| 10 | Tuesday | 10/22 | Home | Sharks | W 4-3 (OT) | |
| 11 | Thursday | 10/24 | Away |  Rangers | L 6-2 | |
| 12 | Friday | 10/25 | Away |  Red Wings | W 2-0 | |
| 13 | Monday | 10/28 | Home |  Coyotes | L 3-2 (SO) | |
| 14 | Friday | 11/1 | Away |  Capitals | L 6-1 | |
| 15 | Saturday | 11/2 | Home |  Islanders | L 1-0 | |
| 16 | Friday | 11/8 | Sweden |  Lightning | L 3-2 | NBCSN |
| 17 | Saturday | 11/9 | Sweden | Lightning | L 5-3 | |
| 18 | Thursday | 11/14 | Home |  Hurricanes | L 5-4 (OT) | |
| 19 | Saturday | 11/16 | Home |  Senators | W 4-2 | |
| 20 | Sunday | 11/17 | Away |  Blackhawks | L 4-1 | |
| 21 | Tuesday | 11/19 | Home |  Wild | L 4-1 | |
| 22 | Thursday | 11/21 | Away |  Bruins | L 3-2 | |
| 23 | Sunday | 11/24 | Away | Panthers | W 5-2 | |
| 24 | Monday | 11/25 | Away | Lightning | L 5-2 | |
| 25 | Wednesday | 11/27 | Home |  Flames | L 3-2 (OT) | |
| 26 | Friday | 11/29 | Home |  Maple Leafs | W 6-4 | |
| 27 | Saturday | 11/30 | Away | Maple Leafs | L 2-1 (OT) | |
| 28 | Monday | 12/2 | Home | Devils | W 7-1 | |
| 29 | Thursday | 12/5 | Away | Flames | L 4-3 | |
| 30 | Saturday | 12/7 | Away |  Canucks | L 6-5 (OT) | |
| 31 | Sunday | 12/8 | Away |  Oilers | W 3-2 (OT) | |
| 32 | Tuesday | 12/10 | Home |  Blues | W 5-2 | NBCSN |
| 33 | Thursday | 12/12 | Home |  Predators | W 4-3 | |
| 34 | Saturday | 12/14 | Away | Islanders | L 3-2 (OT) | |
| 35 | Tuesday | 12/17 | Away | Maple Leafs | L 5-3 | NBCSN |
| 36 | Thursday | 12/19 | Away |  Flyers | L 6-1 | |
| 37 | Saturday | 12/21 | Home | Kings | W 3-2 | |
| 38 | Monday | 12/23 | Away | Senators | L 3-1 | |
| 39 | Friday | 12/27 | Home | Bruins | L 3-0 | |
| 40 | Sunday | 12/29 | Away | Bruins | L 3-2 | |
| 41 | Tuesday | 12/31 | Home | Lightning | L 6-4 | |
| 42 | Thursday | 1/2 | Home | Oilers | W 3-2 (OT) | |
| 43 | Saturday | 1/4 |  Home | Panthers | W 3-2 | |
| 44 | Thursday | 1/9 | Away | Blues | L 5-1 | |
| 45 | Saturday | 1/11 | Home | Canucks | L 6-3 | |
| 46 | Sunday | 1/12 | Away | Red Wings | W 5-1 | |
| 47 | Tuesday | 1/14 | Home |  Knights | W 4-2 | |
| 48 | Thursday | 1/16 | Away | Stars | W 4-1 | |
| 49 | Saturday | 1/18 | Away | Predators | L 2-1 | |
| 50 | Tuesday | 1/28 | Home | Senators | L 5-2 | |
| 51 | Thursday | 1/30 | Home | Canadiens | L 3-1 | |
| 52 | Saturday | 2/1 | Home | Blue Jackets | W 2-1 (OT) | |
| 53 | Tuesday | 2/4 | Home |  Avalanche | L 6-1 | |
| 54 | Thursday | 2/6 | Home | Red Wings | L 4-3 (SO) | NBCSN |
| 55 | Friday | 2/7 | Away | Rangers | W 3-2 | |
| 56 | Sunday | 2/9 | Home | Ducks | L 3-2 | |
| 57 | Tuesday | 2/11 | Home | Red Wings | W 3-2 | |
| 58 | Thursday | 2/13 | Home | Blue Jackets | W 4-3 (OT) | |
| 59 | Sunday | 2/16 | Home | Maple Leafs | W 5-2 | |
| 60 | Tuesday | 2/18 | Away | Senators | L 7-4 | |
| 61 | Saturday | 2/22 | Away | Penguins | W 5-2 | |
| 62 | Sunday | 2/23 | Home |  Jets | W 2-1 | |
| 63 | Wednesday | 2/26 | Away | Avalanche | L 3-2 | NBCSN |
| 64 | Friday | 2/28 | Away | Knights | L 4-2 | |
| 65 | Saturday | 2/29 | Away | Coyotes | L 5-2 | |
| 66 | Tuesday | 3/3 | Away | Jets | L 3-1 | |
| 67 | Thursday | 3/5 | Home | Penguins | L 4-2 | |
| 68 | Saturday | 3/7 | Away | Flyers | L 3-1 | |
| 69 | Monday | 3/9 | Home | Capitals | W 3-2 (SO) | |
| 70 | Thursday | 3/12 | Away | Canadiens | 7 p.m. | |
| 71 | Friday | 3/13 | Home |  Bruins | 7 p.m. | |
| 72 | Sunday | 3/15 | Home | Hurricanes | 5 p.m. | |
| 73 | Tuesday | 3/17 | Away | Hurricanes | 7 p.m. | |
| 74 | Thursday | 3/19 | Away | Panthers | 7 p.m. | |
| 75 | Saturday | 3/21 | Home | Blackhawks | 2 p.m. | |
| 76 | Sunday | 3/22 | Home | Rangers | 3 p.m. | |
| 77 | Tuesday | 3/24 | Away | Canadiens | 7 p.m. | |
| 78 | Thursday | 3/26 | Away | Islanders | 7 p.m. | |
| 79 | Saturday | 3/28 | Away | Wild | 8 p.m. | |
| 80 | Monday | 3/30 | Home | Capitals | 7 p.m. | |
| 81 | Thursday | 4/2 | Away | Devils | 7 p.m. | |
| 82 | Saturday | 4/4 | Home | Flyers | 7 p.m. |
denotes the Sabres will wear their 50th anniversary jerseys
denotes the Sabres’ Black & Red night